Objective To reduce the negative treatment experience of prostate cancer patients undergoing radiotherapy. Methods A total of 115 patients were divided into a control group of 55 and an observation group of 60 according to the admission time.The control group were given routine nursing management of radiation enteritis (RE), while the observation group received optimized management of RE, including building a RE management team, increasing risk assessment for RE, implementing preventive mea-sures, adjusting assessment frequency during radiotherapy, adding education contents, and increasing effect evaluation.The effect was evaluated 2 months after radiotherapy. Results The incidence and severity of RE were significantly lower, whereas quality of life was significantly better in the observation group than those in the control group （all P＜0.05）. Conclusion The optimized ma-nagement of RE can effectively reduce the negative treatment experience of patients and help them successfully complete the therapy.