Objective To explore the effect of online plus offline continuous nursing on self-management ability of patients with maturing autogenous arteriovenous fistula (AVF). Methods A total of 243 patients undergoing AVF creation were selected by conve-nience sampling method, and divided into a control group (n=121) and an intervention group (n=122) according to chronological order. The control group was given routine continuous nursing service, while the intervention group was subjected to online plus offline continuous nursing service:they received offline health education during hospitalization, and online guidance which was delivered through a mobile platform when they were discharged home. The maturity of AVF, AVF self-care ability and patient satisfaction with continuous nursing were compared between the two groups. Results The maturity of AVF, score of each item of AVF self-care ability, and satisfaction with continuous nursing, in the intervention group were significantly higher than those in the control group (P<0.05 for all). Conclusion The combination of online and offline continuous nursing can boost the maturation of AVF, improve self-management ability of patients, and improve patient satisfaction with nursing work.