Objective To explore the status quo and influencing factors of work withdrawal behavior among young and middle-aged patients with sudden deafness, and to provide reference for the formulation of intervention measures. Methods A cross-sectional survey was conducted to enrolled 238 young and middle-aged patients with sudden deafness, who filled out the general information questionnaire, the Work Withdrawal Behavior Scale, the Optimistic Intelligence Quotient Scale, the Adversity Quotient Scale, and the Stress Resilience Quotient Scale. Results The young and middle-aged patients with sudden deafness scored (38.02±5.83) points in work withdrawal behavior. Work withdrawal behavior was negatively correlated with optimistic intelligence quotient, adversity quotient, resilience quotient (all P<0.05). Multiple stepwise linear regression analysis showed that the time to return to work, treatment effect, optimistic intelligence quotient, adversity quotient, and resilience quotient were main influencing factors of work withdrawal behavior in these patients (all P＜0.05). Conclusion The work withdrawal behavior in young and middle-aged patients with sudden deafness is at a high level. The time to return to work, treatment effect, optimistic intelligence quotient, adversity quotient, resilience quotient are main influencing factors. Medical staff can intervene for patients with varied characteristics, so as to reduce their work withdrawal behavior level, and help them better return to society and restore their physical and mental health.