Objective To investigate the effect of early cardiac rehabilitation program on patients with acute myocardial infarction (AMI) treated with intra-aortic balloon pump (IABP). Methods A total of 100 AMI patients treated with IABP were randomly divided into 2 groups of 50 cases each. The control group was given routine rehabilitation training, while the intervention group was additionally given early cardiac rehabilitation training, which included breathing exercises, pulmonary physiotherapy, active and passive muscle strength training, nutritional support, psychological intervention, etc. Results After the intervention, the incidence rate of thromboembolism, pain scores, anxiety and depression scores in the intervention group were significantly lower than those of the control group， while ADL scores, and left ventricular ejection fraction were significantly higher than those of the control group (all P<0.05). Conclusion Early cardiac rehabilitation program can promote the rehabilitation of AMI patients treated with IABP, relieve anxiety and depression, and improve quality of life.