Objective To investigate the status of financial toxicity and explore its influencing factors in cancer survivors, and to provide evidence for developing targeted intervention strategies. Methods A total of 1 065 cancer survivors were recruited and surveyed with demographic questionnaire, the COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy, Connor-Davidson Resilience Scale, Cancer Loneliness Scale and Cancer-related Negative Social Expectations Scale, Perceived Social Support Scale, and the M.D. Anderson Symptom Inventory. Results The total financial toxicity score of the participants was 24.20±7.75, with 535(50.23%) of them suffered from financial toxicity.Multivariate linear regression analysis revealed that, household income per month, disposable household savings, total out-of-pocket payments, knowledge of cost information, tumor site, treatment type, symptom severity, resilience, loneliness and negative social expectations were influencing factors of financial toxicity （P＜0.05 for all）, which accounted for 39.0% of the total variation. Conclusion The prevalence of financial toxicity in cancer survivors is high.Besides demographic, disease-related and financial factors, symptom severity, resilience, loneliness and negative social expectations are also related to financial toxicity.Targeted intervention strategies are needed to prevent or ameliorate financial toxicity of cancer survivors.