Objective To explore the effect of acupuncture at eight points of the nape combined with cognitive rehabilitation training on patients with post-stroke cognitive impairment (PSCI). Methods Totally, 90 patients with PSCI were evenly divided into two groups by the random number table method. The control group was given cognitive rehabilitation training, and on this basis, the intervention group was given acupuncture at eight points of the nape. The intervention lasted for 8 weeks. The effects of the intervention were eva-luated and compared between the two groups. Results The scores of the Mini Mental State Examination (MMSE), the Hasegawa′s Dementia Scale (HDS), the Barthel Index (BI) and the Stroke Impact Scale (SIS) in the intervention group were significantly higher than those of the control group (P<0.05 for all). Conclusion The application of acupuncture at eight points of the nape and cognitive rehabilitation training to PSCI patients can promote the recovery of cognitive function and intelligence, and improve patients′ ADL level and quality of life.