Objective To explore the value of applying an intelligent nursing workflow to perioperative lung cancer patients. Methods In the prospective quasi-experimental design, 80 perioperative lung cancer patients hospitalized during January through April, 2021, were assigned into a control group, who received routine nursing care. Another 101 patients of the same kind hospitalized during May through September, 2021, were assigned into an intervention group, who were subjected to an intelligent nursing workflow with the assistance of the artificial intelligent infusion monitoring system (including patient side infusion monitor, nurse side transfusion monitoring watch, and ward infusion monitoring screen), mobile nursing station construction, intelligent bracelets care systems, logistics robot, intelligent answer robot and ward human-computer interaction motion-sensing simulation system, etc. Results The length of hospital stay, the number of venous therapy accidents in the intervention group were significantly shorter and lower than those in the control group (P<0.05 for both). No adverse events related to intelligent nursing were observed. In terms of nursing quality evaluation, intelligent nursing process also had advantages over the control group: lower incidences of nursing interruption events, less daily call bell use from patients, and higher three-level nursing quality control scores (P<0.05 for all). Conclusion The construction of intelligent nursing workflow is safe and effective for perioperative lung cancer patients. It′s helpful to improve patient safety during hospitalization and quality of nursing care.