Objective To explore the impact of self-transcendence theory-guided nursing interventions on the levels of hope, coping style, self-management behavior and health literacy of patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention. Methods A total of 126 CHD patients were randomized into a control group or an experimental group of 63, receiving either routine nursing care or self-transcendence theory-guided nursing interventions. The levels of hope, coping style, self-management behavior and health literacy were compared between the two groups before and 2 weeks after the intervention. Results After the intervention, the levels of hope, positive coping style, self-management behavior and health literacy were significantly higher, while the score of negative coping style was significantly lower in the experimental group compared with the control group (P＜0.05 for all). Conclusion Self-transcendence theory-guide nursing intervention can enhance hope, positive coping, self-ma-nagement behavior and health literacy in CHD patients.