Objective To evaluate and summarize the best evidence on how to communicate prognosis with advanced cancer patients, and to provide reference for clinical practice. Methods According to the 6S evidence pyramid model, clinical guideline, best practice statement, expert consensus statement and systematic review related to the communication of prognosis to advanced cancer patients were retrieved.Methodological quality of the literature was evaluated and evidence was summarized. Results One best practice statement, two guidelines, and four systematic reviews were included. Nineteen pieces of evidence were summarized and categorized into five aspects:assessment before communication, preparation before communication, communication skills, ways to promote hope, and improving communication ability. Conclusion The best evidence of strategies for prognostic communication in advanced cancer patients can provide reference for clinical personnel, but local adjustment should be made before clinical practice to improve quality of life of patients.