Objective To explore the action path and effect size of factors influencing kinesiophobia in patients with angina pectoris due to coronary heart disease by building a structural equation model, and to provide relevant suggestions for promoting patients′ compliance with cardiac rehabilitation. Methods Using convenience sampling method, 316 angina pectoris patients were included, and asked to fill out the self-assessment lists of general factors questionnaire, Self-rating Anxiety Scale(SAS), Pain Catastrop-hizing Scale(PCS), Multi-dimensional Fatigue Inventory 20(MFI-20), Coronary artery disease Self-management Scale(CSMS), Visual Analogue Scale (VAS) for pain assessment, and the Tampa Scale for Kinesiophobia Heart(TSK-SV Heart). A structural equation model was built to explore action path and effect size of factors influencing kinesiophobia in patients with angina pectoris. Results The patients scored (45.97±11.13) points in kinesiophobia. The structural equation model fitted well (RMSEA=0.067,GFI=0.992,NFI=0.980). Fatigue, pain catastrophization, pain degree, self-management, and anxiety were influencing factors of kinesiophobia in patients with angina pectoris, and the total effect was 0.587, 0.348, 0.245, -0.235, and 0.154, respectively. Fatigue indirectly affected kinesiophobia through pain catastrophization, self-management and anxiety; anxiety indirectly affected kinesiophobia through pain catastrophization; pain degree indirectly affected kinesiophobia through fatigue and self-management; pain catastrophization indirectly affected kinesiophobia through self-management. Conclusion Kinesiophobia of patients with angina pectoris is above medium level. It is an effective way to improve kinesiophobia of patients by reducing their fatigue, pain catastrophization, anxiety and pain degree, and by improving their self-management ability.