Objective To design a "full-chain" nursing follow-up system for the management of lung cancer patients during the perioperative period and evaluate its effects. Methods A total of 138 lung cancer patients visiting the thoracic outpatient clinic in June 2021 were assigned into the control group, who was managed with routine follow-up. Another 124 lung cancer patients visiting the clinic in July 2021 were assigned into the intervention group, who received "full-chain" follow-up intervention: patients′ needs for whole course nursing care were collected, then a "full-chain" nursing follow-up system for lung cancer patients was designed on the basis of the perioperative care needs and the problems encountered in the clinic. The system has 6 functions:patient inclusion, file establishment, online task push, health education, real-time consultation, and back-stage management. Results Among the intervention group, 86.32% were very satisfied with the system, and 3 months after discharge, there were still 73.91% who were followed up. In addition, the total number of times each education video has been fully viewed exceeded 2 342 times; the consultation module received 386 questions, and the doctors and patients interacted 542 times. Comprehensive analysis found that overall length of hospital stay of patients in the intervention group was significantly shorter than that of the control group (P<0.05). Conclusion The "full-chain" nursing follow-up system for patients with lung cancer can promote standardization of whole course patient care and provide a guarantee for the development of homogeneous services.