Objective To develop a care bundle for prevention of gastric retention in intensive care patients and to explore its clinical effect. Methods A total of 72 ICU patients who received enteral nutrition through nasogastric tube were randomized into two groups, with 36 in each.The control group was given routine care, while the experimental group was subjected to a care bundle which was developed using evidence-based methods and Delphi expert consultation to prevent gastric retention. The effect was evaluated after 7 days of intervention. Results A total of 33 subjects in the experimental group and 32 in the control group completed the study.The experimental group had significantly lower incidence of gastric retention, and higher levels of serum total protein, albumin and prealbumin than the control group (P＜0.05 for all). Conclusion The care bundle for prevention of gastric retention in ICU patients is practical, which can reduce gastric retention and improve nutritional status.