Objective To improve practical teaching effect of Adult Nursing in college nursing students. Methods A total of 134 post-secondary nursing students of Grade 2018 were served as a control group and received conventional practical teaching.One hundred and fourteen nursing students of Grade 2019 were treated as an experimental group and given practical teaching using Toulmin argument model. The teaching was divided into three stages (before, during, and after the class) and five procedures (case assertion, evidence presentation, argument analysis, dialectical care, and reflection).At the end of the course, teaching effect was eva-luated. Results The experimental group demonstrated better performance in exams and higher evaluation of the teaching model compared with the control group （P＜0.05,P＜0.01）.The scores of clinical reasoning and reflection were significantly higher in the experimental group after the course than the baseline stage (P＜0.01 for both). Conclusion Using Toulmin′s argument model in practical teaching of Adult Nursing effectively improves teaching quality and effect.