Objective To determine the level and factors associated with work engagement among nurse specialists in Jiangsu pro-vince, and to provide reference for targeted management. Methods A total of 2,472 provincial nurse specialists were investigated using a general data questionnaire and the Nurse Specialists Work Engagement Scale. Results The total average score of work engagement was 4.06±0.46. Multiple linear regression analysis showed that gender, employment type, specialty category, job type, serving at nurse specialist-led clinic and having publications were factors influencing work engagement （P＜0.05,P＜0.01）. Conclusion Work engagement of nurse specialists is at high level and affected by multiple factors.Nursing managers should pay attention to specialized nursing practice of nurse specialists and take targeted measures to support development of specialized nursing, so as to further improve their work engagement.