Objective To improve drug compliance and quality of life of patients undergoing glioma surgery. Methods A total 130 patients undergoing glioma surgery were divided chronologically into a control group of 64 to receive conventional nursing care and an observation group of 66 to receive family empowerment intervention in combination with information service.The effect was eva-luated 6 months after discharge from hospital. Results The observation group had significantly higher drug compliance compared with the control group (P＜0.01).Seven dimensions of fatigue, pain, insomnia, loss of appetite, physical functioning, mood and general health in quality of life were significantly better in the observation group than those in the control group （P＜0.01 for all）. Conclusion Implementing family empowerment intervention in combination with information service in patients after glioma surgery is conducive to improving medication compliance and quality of life of patients.