Objective To investigate the status of discharge disposition in patients with stroke and identify its predictors, so as to provide reference for clinical medical staff implementing discharge planning. Methods A total of 238 stroke patients in neurology department were selected using cluster sampling, then their general information, disease-related information, functional data and discharge disposition were investigated. Results There were 84 patients (35.3%) encountered discharge disposition change, there were significant differences in ADL function, mobility, tube, comorbidities and economic status among the discharged patients living in home, primary health care institutions and rehabilitation facilities (P<0.05, P<0.01). Logistic regression analysis showed that, ADL function, risk of pressure injury and living condition were predictors of discharge disposition in stroke patients (P<0.05, P<0.01). Conclusion The incidence of discharge disposition change is high in patients with stroke, and those patients with worse ADL function, high risk of pressure injury at admission and lived alone are prone to encounter the change. Clinical staff should help patients to choose an appropriate discharge disposition according to their severity of disease, mobility function, care support and economic status, and it is necessary to strengthen the construction of medical health service after discharge and referral system at the same time.