Objective To explore the effect of case management model in specialized nursing clinics on return visit and medication compliance for patients with permanent pacemaker implantation. Methods A total of 134 patients with permanent pacemaker implantation for the first time were divided into a control group and an intervention group using a random number table, with 67 cases in each group. The control group was given routine follow-up via WeChat or telephone, while the intervention group was followed up using case management model in specialized nursing clinics, which included follow up and individualized health education through online and specialized nursing clinics. The return visit rates and medication compliance between the two groups at 1, 3, and 6 months after discharge were compared. Results The return visit rate and medication compliance at 1, 3, and 6 months after discharge in the intervention group were significantly higher than those in the control group (P<0.05, P<0.01). Conclusion Implementing case management model in specialized nursing clinics for patients with permanent pacemaker implantation, promotes the transition and whole-process management of specialized nursing after discharge, and can significantly improve their postoperative return visit rate and medication compliance.