Objective To explore the effect of nutrition management bundles for nasopharyngeal carcinoma (NPC) patients undergoing concurrent radiotherapy and chemotherapy. Methods A total of 134 NPC patients undergoing initial treatment of concurrent radiotherapy and chemotherapy were conveniently selected and randomized into a control group (n=66) and an experimental group (n=68). The control group was given routine nutrition management, while the experimental group received nutrition management bundles, which consisted of nutrition education, nutrition screening, ensuring nutrition intake, prevention and management of therapy-related symptoms, rehabilitation exercise guidance and psychological support. The standard reaching rate of nutrition intake, the incidence of malnutrition and delayed course of treatment, Body Mass Index (BMI), hemoglobin, serum albumin and serum prealbumin between the two groups before and after the intervention were assessed and compared. Results After the intervention, the incidences of malnutrition and delayed course of treatment in the experimental group were significantly lower than those in the control group, while its BMI, hemoglobin, serum albumin, serum prealbumin, the standard reaching rate of 75% energy intake and 75% protein intake were significantly higher than those of the control group (P<0.05，P<0.01). Conclusion The nutrition care bundles can significantly improve the nutritional status of NPC patients undergoing concurrent radiotherapy and chemotherapy,and reduce their incidence of malnutrition.