Objective To explore the effect of brain and heart health manager-led stroke risk screening clinic. Methods In 2019, a cli-nic for screening stroke risk was established, then nurses were selected and trained as brain and heart health manager.Work process and norms were formulated.Brain and heart health managers run the clinic to assess the risk of stroke in patients, and provided comprehensive assessment and targeted education for those at medium to high risk of stroke. Results Until December 2021, 3,370 patients were screened, of whom 2,939 were at medium to high risk of stroke and documented. From January to May 2021, 256 patients were followed up, and their smoking cessation, alcohol cessation, dietary taste, exercise, blood pressure measurement, blood pressure and blood glucose control rates had significant differences before and after the screening intervention (P＜0.05,P＜0.01). Conclusion The practice of stroke risk screening clinic can enhance awareness of patients about risk factors of stroke, which has a positive significance on changing unhealthy lifestyle and managing high risk factors.