Objective To explore the effects of applying "two classrooms" ideological and political theory education model based on Constructivism theory for the course of internal medical nursing. Methods Two classes of students enrolled in 2019 were randomly divided into an experimental group (n=76) and a control group (n=78). The control group was subjected to traditional ideolo-gical and political theory education for the course of internal medical nursing, while the experimental group was subjected to "two classrooms" ideological and political theory education based on Constructivism theory for the same course. The "two classrooms" model worked through a 3-pronged approach of "perception-expression-sublimation" to achieve the goal of externalization in the form and internalization in the heart. At the end of the semester, humanistic caring ability, professional attitude and results of written and skill exams were compared between the two groups. Results The scores of humanistic caring ability and professional self-concept in the experimental group were significantly higher than those in the control group （P＜0.05，P＜0.01）, though there were no significant differences in results of written and skill exams between the two groups (P>0.05). Conclusion The "two classrooms" ideological and political theory education model based on Constructivism theory can effectively improve students′ humanistic caring ability, solidify their professional thought, and fulfill the goal of professional and moral collaborative education.