Objective To explore the status and the influencing factors of frailty in patients with gastrointestinal tumors, and to provide reference for clinical staffers to take measures against frailty. Methods Totally, 343 patients with gastrointestinal tumors were selected via convenience sampling method, and surveyed with a demographic questionnaire, the Frailty Phenotype, the Patient-Generated Subjective Global Assessment (PG-SGA) and the Hospital Anxiety and Depression Scale (HADS). Results Totally 218 patients with gastrointestinal tumors suffered from frailty and the prevalence was 63.56%. Logistic regression analysis showed that age, albumin levels, education levels, treatment methods, depression, and PG-SGA scores were influencing factors of frailty（P＜0.01 for all）. Conclusion The prevalence of frailty in patients with gastrointestinal tumors is high. Attention should be attached to patients with advanced age, on chemotherapy/radiotherapy and other treatments, with depression, or with a PG-SGA score ≥ 4. Targeted intervention measures in accordance with the influencing factors of frailty should be taken to prevent or ame-liorate frailty of patients.