Objective To explore the effect of multidisciplinary nutritional management based on nutritional risk levels for patients with chronic liver failure. Methods A total of 51 patients hospitalized during April through August 2020 were recruited as the control group, and 52 patients during September 2020 through March 2021 as the intervention group. The control group was given routine nutritional care, while the intervention group was subjected to a multidisciplinary nutritional management program based on nutritional risk levels. The malnutrition risk scores as measured by the Royal Free Hospital-Nutritional Prioritizing Tool (RFH-NPT), Child-Pugh scores and nutrition-related laboratory indicators before and after the intervention, incidence rate of hepatic encephalopathy, and counts of readmission within 6 months, were compared between the two groups. Results After intervention, the RFH-NPT scores, hemoglobin levels, albumin and pre-albumin levels in the intervention group were significantly higher, while the counts of readmission within 6 months were significantly lower, than those in the control group (P<0.05,P<0.01). Conclusion Multi-disciplinary nutritional management program based on nutritional risk level can effectively improve nutritional status of patients with chronic liver failure and reduce re-admission within six months.