Objective To evaluate the effect of hospital alliance collaborated hypertension management mode in rural patients with hypertension, and to explore an effective method for promoting health management in rural patients with hypertension. Methods Totally, 470 patients with primary hypertension hospitalized in 15 medical institutions of a hospital alliance were assigned to a control group or an intervention group chronologically, with 235 patients in each group.The control group was given conventional nursing intervention, while the intervention group received collaborated hypertension management provided by the intervention team involving staff from both hospital and 15 grass-root health institutions. Blood pressure and self-management behavior in both groups were evaluated before and at 6-month of intervention. Results The intervention had significantly lower blood pressure, but higher self-management behavior compared with the control group after the intervention (P＜0.01 for both). Conclusion Hospital alliance collaborated hypertension management mode contributes to enhancing self-management behavior of rural patients with hypertension and achieving blood pressure control.