Objective To explore the effect of WeChat driven three-stakeholder-groups, double-track, interactive nursing care for COPD patients. Methods A total of 138 COPD patients were randomly divided into a conventional group and an intervention group, with 69 in each.The conventional group was given routine nursing services after discharge, while the intervention group received WeChat driven three-stakeholder-groups, double-track, interactive nursing care that included continuous care of the hospital and community care involving specialty nurse in the hospital, community nurse and the patient.Disease-related knowledge, COPD Assessment Test (CAT) score, six-minute walk distance and Borg dyspnoea score were measured before and after 6 months of intervention. Results The intervention group had significantly higher disease-related knowledge and 6-min walk distance, whereas lower CAT score, and Borg score compared with the conventional group （P＜0.05,P＜0.01）. Conclusion WeChat driven three-stakeholder-groups, double-track, interactive nursing care for COPD patients can promote their disease-related knowledge and boost recovery.