Objective To systematically review and synthesize qualitative research on nurses′ experiences of patient suicide and to provide evidence for designing effective coping strategies. Methods We searched electronic databases as Cochrane Library, Ovid, CNKI, etc. to retrieve qualitative research on nurses′ experiences of patient suicide. The JBI Critical Appraisal Checklist for Qualitative Research was used to evaluate the quality of studies and then data synthesis was performed. Results Ten articles were eligible.Sixty-three findings were extracted from the studies and were integrated into 9 new categories and finally 4 themes were elicited:patient suicide makes nurses feel stressed through personal and social factors; individual and social coping resources affect nurses′ reaction to patient suicide; due to different stressors and coping resources, nurses adopt positive or negative coping styles; physical, psychological and behavioral changes of nurses after managing patient suicide. Conclusion Nurses themselves, nursing managers and hospitals should timely identify nurses′ stressors and coping resources, pay more attention to their coping styles and stress reactions, and provide systematic countermeasures in an effort to help them restore physical and mental health.