Objective To explore the effect of scenario simulation combined with ′pithy formula′ on cardiopulmonary resuscitation (CPR) training for nursing interns in the intensive care unit. Methods Eighty nursing students were randomly divided into a control group and an observation group, with 40 in each.The control group was given routine CPR training, while the observation group received CPR training by using scenario simulation and self-designed ′pithy formula′.Theoretical and practical test scores, the error rate of operation, and time to completion of each rescue procedures were compared between the two groups after the intervention.Feedbacks to the novel teaching method in the observation group were collected. Results The observation group had significantly higher theoretical and practical test scores, lower error rates of environmental assessment and reversal of sequence of procedures, and shorter time to completion of rescue procedures compared with the control group （P＜0.01 for all）.All students in the observation group satisfied with the novel teaching method. Conclusion Scenario simulation combined with pithy formula can improve the effect of cardiopulmonary resuscitation training and satisfaction of nursing students.