Objective To summarize the best evidence on home oxygen therapy practice for children with bronchopulmonary dysplasia, and provide practical reference for nursing staff. Methods We formulated clinical questions and structured them with PIPOST model, and retrieved relevant evidence on home oxygen therapy for children with bronchopulmonary dysplasia. Then we picked publications that met the inclusion and exclusion criteria. Researchers who had attended training on evidence-based nursing appraised the quality of the included literature, and extracted data from the literature. Evidence was refined and summarized from lite-rature that met quality standards. Results Finally, 8 publications were included, including 1 clinical decision report, 3 guidelines, 1 evidence summary report, and 3 expert consensus reports. A total of 29 pieces of best evidence were extracted and grouped into three dimensions of preparation for discharge from hospital, implementation of home oxygen therapy, and oxygen reduction and cessation. Conclusion The best evidence for home oxygen therapy for children with bronchopulmonary dysplasia, can provided evidence-based references for medical institutions to establish protocols, processes and practice standards for home oxygen therapy.