Objective To develop a discharge planning service plan for patients with urostomy after radical cystectomy, and to investigate its clinical effect. Methods Through literature retrieval, retrospective analysis, qualitative interviews, Delphi based expert consultation, and clinical empirical study, the discharge planning service plan for urostomy patients after radical cystectomy was formulated. A non-concurrent controlled study involving 140 cases was conducted. Sixty-four patients in the control group received routine discharge care, while 76 patients in the intervention group was subjected to the discharge planning service plan carried out by a multidisciplinary cooperative management team. Results The scores of discharge readiness, quality of discharge instructions, urostomy self-care ability and satisfaction in the intervention group were significantly higher than those in the control group, while the readmission rate within 30 days after discharge were significantly lower in the former group （P＜0.05，P<0.01）. The risk ratio for the incidence rate of complications was 0.361, favoring the intervention group. Conclusion The rollout of discharge planning service for patients with urostomy after radical cystectomy can improve the level of discharge readiness, and make discharge outcomes better.