Objective To translate the Tilburg Pregnancy Distress Scale (TPDS) into a Chinese version and verify its reliability and validity. Methods The English version of TPDS was translated and cross-culturally adapted according to the Brislin translation model to form a Chinese version .A total of 169 pregnant women attending antenatal care were surveyed with the Chinese version of TPDS to assess the reliability and validity of the Chinese version. Results The Chinese version of TPDS included 3 dimensions of health needs, emotional needs, and daily living needs, totaling 15 items. The Cronbach′s α coefficient of the Chinese version scale was 0.819, and the test-retest reliability coefficient was 0.962. The scale level content validity index (S-CVI) was 0.920, and the item-level content validity index (I-CVI) was 0.857-1.000. The cut-off point of the Chinese version was 23. Conclusion The Chinese version of TPDS has good reliability and validity, and can be used as a valid and reliable measurement tool to assess psychological distress of pregnant women in China.