Objective To evaluate the effect of internet-based dyadic cognitive behavioral therapy (ICBT) on psychological distress and quality of life of young cervical cancer patients undergoing chemotherapy. Methods A convenience sampling of 106 cervical can-cer patients receiving chemotherapy and their spouses were randomly assigned to either an intervention group (53 couples) or to a control group (53 couples).The control group was given conventional psychological care, while the intervention group received ICBT for 8 weeks.Before and 1 month after the intervention, the Distress Thermometer （DT）and the Functional Assessment of Cancer Therapy with Cervical Cancer Subscale (FACT-CX) were utilized to measure psychological distress and quality of life. Results After the intervention, the positive rate of psychological distress was significantly lower, whereas quality of life was significantly higher in the intervention group than those in the control group after the intervention （P＜0.05,P＜0.01）. Conclusion Implementation of ICBT for young couples facing cervical cancer can alleviate psychological distress of patients and enhance their qua-lity of life.