Objective To develop a scale to measure work engagement in Chinese specialty nurses based on our culture background, and to test its validity and reliability. Methods The initial scale was formulated by literature review, semi-structured interview and expert consultation. Totally, 2,260 specialty nurses registered in Jiangsu Province specialty nurse online training platform were invited to complete the questionnaire survey. Results Exploratory factor analysis revealed 5 factors, totaling to 32 items, which explained 63.281% of the accumulated variances. Confirmatory factor analysis showed that the 5-factor model fit well, and the mo-del fit indices were χ2/df=2.462,GFI=0.941,NFI=0.955,CFI=0.964, RMSEA=0.041. The item-level content validity index (CVI) ranged from 0.834 to 1.000, and the scale-level CVI was 0.842. The Cronbach′s α coefficient for the total scale was 0.958, and the spilt-half reliability coefficient was 0.895. Conclusion The Specialty Nurse Work Engagement Scale is valid and re-liable to measure work engagement in specialty nurses.