Objective To explore the effect of reading therapy on benefit finding, caregiving burden and negative emotions in caregi-vers of advanced lung cancer patients. Methods Eighty caregivers of patients with advanced lung cancer were assigned to a control group or an intervention group of 40 according to the ward where the patients were hospitalized, receiving either conventional health education or reading therapy respectively.The Perceived Caregiving Benefits Scale, Zarit Caregiver Burden Interview (ZBI), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were utilized to evaluate the effect in three steps of before intervention and five and nine weeks after start of intervention. Results The scores of perceived caregiving benefits, ZBI, SAS and SDS had significant differences between the two groups after the intervention (P＜0.01 for all). Conclusion Reading therapy can improve benefit finding of caregivers of advanced lung cancer patients, relieve their anxiety, depression and caregiving burden.