Objective To provide an overview of the available researches on the application of e-Health in the management of patients with chronic diseases, and to provide references for related researches and applications. Methods We searched relevant literature available in such academic databases as PubMed, CINAHL, Embase, Web of Science, MEDLINE, Cochrane Library, US Natio-nal Guidelines Database, China National Knowledge Infrastructure(CNKI), and Wanfang. Results We included 35 relevant papers.We found that e-Health in the management of chronic diseases came mainly in two forms, including mobile health and tele-Health. e-Health provided the patients with chronic diseases with self-management guidance, health information tracking, online peer support resources, medical health resources, and psychological support. The strategies for e-Health in chronic disease management included taking a patient-needs-oriented approach, building a multidisciplinary management team, privacy protection, training and financial incentives. The evaluation for e-Health in chronic disease management included clinical outcomes, economic outcomes, compliance and feasibility of intelligent devices, and patient satisfaction. Conclusion e-Health plays a positive role in the management of patients with chronic diseases.However, further improvement, as in meeting patients′ individual needs, providing conve-nient download channels, and making operating interfaces more user-friendly, is required.