Objective To investigate the effect of applying independent wheelchair transfer technique to stroke patients with hemiplegia. Methods A total of 72 stroke patients with hemiplegia were subjected to wheelchair transfer training, and 66 of them (31 in the control group, and 35 in the intervention group) completed 8-week training.The control group received conventional wheelchair transfer training, while the intervention group received independent wheelchair transfer training.The Barthel Index, Stroke Self-efficacy Questionnaire (SSEQ) and unarmed muscle strength test (MMT) were used to measure the patients before the intervention, 4 and 8 weeks into the intervention. Results At 8 weeks into the intervention, the Barthel Index scores, stroke self-efficacy scores and muscle strength scores and gradings presented significant group effect, time effect, and group by time effect between the 2 groups (P＜0.05 for all). Conclusion Independent wheelchair transfer training, could effectively improve the activity of daily living level, self-efficacy level and muscle strength of stroke patients with hemiplegia, which was helpful to speed up rehabilitation of patients.