Objective To explore the effect of applying virtual simulation technology combined with intelligent vocational education cloud classroom in teaching of childbirth nursing care. Methods The first class of 74 students enrolled in 2019 were viewed as the control group, and were subjected to traditional teaching model.The second class of 76 students enrolled in the same year were treated as the intervention group, and were subjected to a teaching model which combined virtual simulation technology and intelligent vocational education cloud classroom.At conclusion of the course, the students were evaluated with knowledge exam and skill exam.And the intervention group was additionally surveyed for their appraisal of the teaching method they had received. Results The knowledge exam and skill exam scores of the intervention group were significantly higher than those of the control group (P＜0.05，P＜0.01); more than 70% of the students in the intervention group gave a positive feedback of the model. Conclusion The teaching model of virtual simulation technology combined with intelligent vocational education cloud classroom, could improve students′ learning experience, their knowledge and skill levels, clinical nursing competence, and the teaching quality of the childbirth nursing course.