Objective To investigate medical undergraduates′ knowledge of patient-reported outcomes (PRO). Methods A total of 315 undergraduate medical students were surveyed with a self-designed questionnaire of PRO knowledge and needs, and the Outcome Measures Questionnaire. Results Among the respondents, 195(61.90%) were able to correctly select the definition of PRO and 190(60.32%) were able to correctly select the contents of PRO.The total score of attitude towards PRO was 84.13±0.40, with the item-level score averaging 3.82±0.01. Whether the students had internship experience and the college year they were in were significant factors affecting the attitude of undergraduate medical students towards PRO （P＜0.05,P＜0.01）. Conclusion Undergraduate medical students had some knowledge of PRO and were willing to learn related knowledge, although some did held negative attitudes.Development of related elective course may improve students′ understanding and precise utilization of PRO in clinical settings.