Objective To investigate the current status and influencing factors of demoralization syndrome in cancer patients. Methods A total of 250 cancer patients were surveyed by utilizing the Chinese version of the Demoralization Scale Ⅱ （DS-Ⅱ） and the Edmonton Symptom Assessment System （ESAS）. Results The median (P25 and P75) of demoralization score was 10.0 (7.0,12.0). The incidence of moderate and severe demoralization syndrome was 47.20% and 4.00% respectively. Multiple linear regression indicated that gender, education level, monthly average income, pain, tiredness, depression, anxiety and decreased well-being were the influencing factors of demoralization syndrome in cancer patients（P＜0.05，P＜0.01）. Conclusion The prevalence of demoralization syndrome was relatively high in cancer patients. Medical staff should take targeted measures to reduce the demoralization level of cancer patients and improve their quality of life.