Objective To explore the effect of closed-loop management of medical consumables in the operating room under the payment based on the DRG. Methods An information technology assisted, closed-loop management system for medical consumables was designed, including the generation of two-dimensional code of consumables, establishment of basic information maintenance, stock management, and use query. The use process of medical consumables was monitored and traced through the trace management of each link. The stocktaking time, the incidence of wrong billing events, time for billing, and the user satisfaction before and after the application of the system were compared. Results After the implementation of closed-loop management of medical consumables, the daily average stocktaking time and time for billing were significantly shortened, the incidence of wrong billing events was significantly reduced, and user satisfaction was significantly enhanced （P＜0.01 for all）. Conclusion The application of closed-loop management of medical consumables in the operating room based on the DRG is efficient and precise, and it promotes user satisfaction.