Objective To construct a self-management education model for patients with heart failure in physician-nurse collaborative outpatient clinic and to explore its influence on self-care behavior of patients. Methods A total of 263 patients attending a heart failure outpatient clinic which was run by physicians and nurses working together were chronologically divided into a control group of 131 and an intervention group of 132.The control group received routine treatment and health education, while the intervention group were subjected to self-management education program including outpatient education, online lectures, and education with shining example. Before and 3 months after the intervention, the Self-Care of Heart Failure Index, Atlanta Heart Failure Know-ledge Test-V2,and Kansas City Cardiomyopathy Questionnaire were used to evaluate the effects. Results After 3 months of intervention, the intervention group had better self-care behavior,heart failure knowledge and quality of life compared with the control group （P＜0.01 for all）. Conclusion The self-management education model for patients with heart failure in the physician-nurse collaborative outpatient clinic can improve self-care behavior, disease-related knowledge and quality of life of patients, which ensures continuous high-quality care.