Objective To explore the current status of cancer-related anorexia among nasopharyngeal carcinoma patients receiving radiotherapy and chemotherapy, and to probe into its influencing factors. Methods Totally, 200 nasopharyngeal carcinoma patients receiving radiotherapy and chemotherapy were surveyed using the Functional Assessment of Anorexia Cachexia Therapy-Anorexia Cachexia Subscale (FAACT-ACS), M.D. Anderson Symptom Inventory-Head & Neck Module, and the Hospital Anxiety and Depression Scale. Results The total score of cancer-related anorexia in nasopharyngeal carcinoma patients receiving chemotherapy and radiotherapy was （20.99±6.70） points, and the incidence rate was 62.5%; the item-level symptom distress score averaged （6.16±1.29） points,being at moderate level; the anxiety and depression scores were respectively （11.70±3.12） and （11.18±3.43） points. The results of multiple linear regression analysis showed that patient′s education level, radiation-induced oral mucositis, symptom distress, anxiety and depression were the main influencing factors of cancer-related anorexia （P＜0.05，P＜0.01）. Conclusion Medical staff should pay attention to cancer-related anorexia in nasopharyngeal cancer patients receiving radiotherapy and chemotherapy, and formulate targeted, effective, and systematic appetite-enhancing intervention strategies, so as to improve the quality of life of patients.