Objective To establish a screening platform for covert hepatic encephalopathy in liver cirrhosis patients, and to explore the effect of applying the platform-based early intervention to patients with liver cirrhosis. Methods A total of 355 patients with liver cirrhosis were randomized into two groups:the control group （n=180） received routine follow-up service, while the intervention group （n=175） was subjected to follow-up management based on the covert hepatic encephalopathy screening platform. The intervention effect was evaluated 6 months into follow-up service. Results Six months into follow-up service, the intervention group had lower re-admission rate, incidence rate of hepatic encephalopathy, and mortality rate than those of the control group （P＜0.05 for all）. Conclusion The screening platform for covert hepatic encephalopathy establishes an integrated management model of early screening, regular follow-ups, health education, and nurse-patient communication, which can realize early screening and intervention of covert hepatic encephalopathy, and improve clinical outcomes of patients.