Objective To explore nursing management strategies for emergency events with backing from the National Medical Center for Major Public Health Events, and to explore the effect of such practice. Methods Backed by the National Medical Center for Major Public Health Events, we refined the nursing emergency management mechanism, built up a set of nursing management strategies for emergency events, with measures including forging emergency response, setting up multi-point triggering, working with a grid based approach, setting up fixed positions and responsibilities, opening green channel, boosting efficient collaboration of medical personnel, building specialized nursing teams, and guarding physical and mental health of patients, etc.Then the management strategies were put into emergency rescue practice for a windstorm disaster. Results Upon receiving the windstorm disaster rescue mission, 50 nurses were assembled within 30 minutes, and the buffer ward was ready within 1 hour.Six waves of wounded persons, totaling 22 persons, received treatment within 3 hours, among whom, 11 were admitted to hospital.The average emergency treatment time and average emergency stay time was 8.18 minutes and 10.91 minutes respectively.During hospitalization, there were no nursing related complications, adverse events or post-traumatic stress disorder reported. Conclusion The comprehensive nursing management mechanism built with backing from the National Medical Center for Major Public Health Events, is conducive to active and efficient response to emergency events.