Objective To describe current situation and influencing factors of readiness for return-to-work in young and middle-aged lymphoma patients, and to provide references for clinical intervention. Methods Convenience sampling method was used to select 205 lymphoma patients aged 18-59 years from the oncology department of two first class hospitals in Zhengzhou.The general information questionnaire, Readiness for Return-To-Work (RRTW) scale, Family Hardiness Index and General Alienation Scale were used to survey the patients. Factors associated with readiness for return-to-work in the patients were analyzed. Results As a whole, 69.76% of the patients were at pre-contemplation, or contemplation stage with regard to readiness for return-to-work. Family resilience and its dimensions were positively correlated with readiness for return-to-work, while social alienation was negatively correlated with readiness for return-to-work （P＜0.05,P＜0.01）.Logistic regression analysis showed that, age, disease stage, family resilience, social alienation, and participation in tumor rehabilitation activities had an impact on readiness for return-to-work （P＜0.05,P＜0.01）. Conclusion The level of readiness for return-to-work in young and middle-aged lymphoma patients needs to be improved. Age, stages of the disease,family resilience and social alienation were main influencing factors of readiness to return-to-work. Medical staff should strengthen hospital-community connections, establish a whole process of diagnosis, treatment, nursing, and rehabilitation services for lymphoma patients, and give targeted rehabilitation interventions, so as to improve their readiness for return-to-work, and promote their return to social life.