Objective To investigate care dependence of bladder cancer patients with abdominal wall stoma due to urinary diversion surgery, and to analyze the influencing factors. Methods From May 2020 to May 2021, 168 patients with abdominal wall stoma due to urinary diversion surgery for bladder cancer were selected and asked to fill out the general information questionnaire, the Care Dependency Scale, the Self-Esteem Scale, the Post-Traumatic Stress Disorder Checklist-Civilian Version and Personal Mastery Scale.The influencing factors of care dependence of the patients were analyzed by multiple linear regression model. Results The total score of care dependence of the patients was （57.07±8.31）.Multiple linear regression analysis showed that age, education levels, comorbidities, self-esteem level, post-traumatic stress disorder and personal mastery were influencing factors of care dependence in patients with abdominal wall stoma due to urinary diversion surgery for bladder cancer, with the variables explaining 66.1% of the total variation. Conclusion The incidence rate of care dependence in patients with abdominal wall stoma due to urinary diversion surgery for bladder cancer is high. Clinical nurses should develop effective intervention measures according to patients′ age, education level, comorbidities, self-esteem level, the presence of post-traumatic stress disorder and personal mastery level, so as to reduce patients′ care dependence and improve their quality of life.