Objective To establish a safe interhospital transport scheme for patients receiving extracorporeal membrane oxygenation (ECMO), and to explore its clinical application effect. Methods A safe interhospital transport scheme for patients receiving ECMO was constructed. A total of 60 patients receiving ECMO in need of interhospital transport were enrolled for the non-concurrent controlled trial, and divided into a control group (spanning from July 2018 through July 2019, interhospital transport conducted without the scheme), and an intervention group (spanning from October 2019 through October 2020, interhospital transport conducted with the scheme). Pre-and-post differences in medical staffers′ ECMO knowledge score and changes in efficiency of interhospital transport, and incidence rates of complications related to interhospital transport between the two groups, were compared. Results Medical staffers′ ECMO knowledge scores measured post-implement of the scheme were significantly higher than those measured pre-implement.The time for catheter prefilling and catheterization, in the intervention group was significantly shorter than in the control group (P＜0.05,P＜0.01). The incidence rate of adverse events related to transport in the intervention group was lower than in the control group, though of no significant difference. Conclusion The safe interhospital transport scheme can improve the knowledge level of staffers involved in interhospital transport, enhance the efficiency of interhospital transport, and reduce the incidence rate of adverse events related to interhospital transport.