Objective To review the application of evidence regarding prevention and nursing care of postoperative sore throat due to the use of endotracheal intubation during general anesthesia, analyze the barriers and facilitators, and to provide reference for PSG after general anesthesia. Methods According to the methodology of evidence-based nursing, a total of 20 pieces of evidence were formed, and 16 review indicators were formulated. Then 142 patients and 140 doctors and nurses were clinically reviewed, and the i-PARIHS framework was used to analyze barriers and facilitators. Results As many as 10 indicators had a compliance rate ＜60%.The main barriers to change included:（1）some evidence required changes to processes and systems;（2）some evidence was not included in the evaluation system;(3) evidence did not described the methods and processes in details;(4) evidence might conflict with the working environment of medical care.The barriers reported by the recipients included the lack of knowledge related to health care, denial of the values of the evidence, the lack of effective multidisciplinary and multi-team assistance,etc. The barriers to the organizational environment included: the lack of relevant disease treatment support systems in the hospital,the lack of relevant equipment, as well as the lack of related processes, graphics, and educational materials in departments. Conclusion Clinical medical staff should adopt multidisciplinary cooperation, fully consider the barriers in each department, and develop relevant technologies, procedures and standards, so as to promote clinical transformation of evidence.