Objective To explore the effect of experiential teaching of stroke complications on compliance with warfarin therapy in patients with atrial fibrillation. Methods A total of 122 atrial fibrillation patients on oral warfarin therapy were divided into 2 group per randomization of the units they were in.The control group(n=59) was given routine education, while the intervention group (n= 63) was additionally given experiential teaching of stroke complications.Six months into the intervention, the 2 groups were eva-luated 3 months and 6 months into the intervention. Results Medication compliance score measured at 3 months and 6 months into the intervention in the intervention group were significantly higher than the control group (P＜0.05 for both). Six months after discharge, 2 cases in the control group versus zero case in the intervention group developed stroke. Conclusion Application of experiential teaching of stroke complications can improve compliance with warfarin therapy in patients with atrial fibrillation.