Objective To explore the effects of case management based on multidisciplinary collaboration on quality of life of surgical patients with thyroid associated ophthalmopathy. Methods Totally,99 surgical patients with thyroid associated ophthalmopathy were divided into a control group （n=50） and an intervention group （n=49） according to the hospitalization periods.The control group was given traditional treatment and care, while the intervention group was given case management based on multidisciplinary collaboration.The quality of life, SAS and SDS score, hospital stays and satisfaction with nursing service were compared between the two groups. Results SAS and SDS score, and hospital stays in intervention group were significantly lower and shorter than in control group, while quality of life and satisfaction with nursing service in the former group were significantly higher than latter group （P＜0.05，P＜0.01）. Conclusion Case management based on multidisciplinary collaboration can improve quality of life of surgical patients with thyroid associated ophthalmopathy, relieve anxiety and depression, reduce hospital stays and improve patient satisfaction with nursing service.