Objective To explore the effect of grid-based management combined with standard operating procedure （SOP） in management of catheter fixation and quality control. Methods A catheter fixation quality control team was established and formulated stan-dard operating procedures （SOP） for catheter fixation.Each of the 38 units from 5 departments was seen as a grid whose nursing staffers were given training, and each grid was subjected to grid-based management. Results The rate of unplanned extubation saw a decline from 2017 through 2020. Scores of catheter fixation quality inspection in 2018 through 2020 were significantly higher than in 2017（P＜0.05 for all）.The proportion of unplanned extubation due to failed securement was significantly reduced after implementation of grid-based management combined with SOP （P＜0.01）. Conclusion The implementation of grid-based management combined with SOP for catheter fixation realized homogenous and standardized fixation and quality control of catheters in all grid units across the whole hospital, reduce the rate of unplanned extubation, and improved the quality of catheter management.