Objective To explore the effect of applying daily safety sharing based on information system in management of adverse nursing events. Methods With comparative-historical design, 22 nursing units, which had a hospitalization of 11 992 patients spanning from October 2018 to September 2019, were seen as the pre-sharing group.During the period, the adverse nursing events were compiled by the department of nursing, and shared quarterly in quality reports.The head nurses of the units had limited access to check on the adverse nursing events occurring only in their units. The same 22 nursing units, which had a hospitalization of 13 527 patients spanning from October 2019 to September 2020, were seen as the post-sharing group.During the period, the head nurses of the units logged in the adverse events sharing platform before 8:00 am, and had full access to check on all the adverse nursing events occurring within the last 24 h.Then after morning handovers, the head nurses shared the adverse nursing events that were highly or potentially related with their own units, with their nurses, and discussed the process and management mea-sures of such kind of adverse nursing events. Results The relative risk ratio (RR) for adverse nursing events in the 2 groups stood at 0.629, 95%CI (RR):0.492-0.804. The severity of adverse nursing events in the post-sharing group was significantly milder （P＜0.01） than in the pre-sharing group.After daily safety sharing practice, the nurses working in the units saw significant improvement in the scores of attention to adverse nursing events, attitude towards solving adverse events, ability to handle adverse events, and personal growth （P＜0.01 for all）. Conclusion Daily safety sharing based on information system provides a platform for adverse event communication, significantly reduces the incidence rate and severity of adverse events, and improve nurses′ safety awareness and ability to handle adverse events.